Available agents and dosing frequency. It belongs to a class of drugs known as alpha agonists. The recommended dose is one drop of brimonidine tartrate ophthalmic solution 0.2% in the affected eye(s) three times daily, approximately 8 hours apart. Brimonidine ophthalmic is in a class of drugs called alpha-2 adrenergic agonists. Don't delay your care at Mayo Clinic. WebMD provides common contraindications for Brimonidine Ophthalmic (Eye). Brinzolamide has a molecular weight of 383.5. It has an osmolality of 250-350 mOsmol/kg and a pH of 7.4-8.0 (0.1%) or 6.6-7.4 (0.15%). Find out what health conditions may be a health risk when taken with Brimonidine Ophthalmic (Eye) Alphagan comes as eyedrops. In solution, ALPHAGAN® P (brimonidine tartrate ophthalmic solution) has a clear, greenish-yellow color. Brimonidine works by allowing better fluid drainage from within the eye and also by decreasing the amount of fluid formed in the eye. Schedule your appointment now for safe in-person care. Find patient medical information for brimonidine ophthalmic (eye) on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. It is a white powder, which is insoluble in water, very soluble in methanol and soluble in ethanol.. Brimonidine tartrate is described chemically as: 5-bromo-6-(2-imidazolidinylideneamino) quinoxaline L-tartrate. [L6544] This characteristic gives the drug some therapeutic advantages, since it reduces the risk of systemic side effects, such as systemic hypotension, bradycardia, and sedation. Brimonidine Ophthalmic drops, solution 0.15pct Drug Medication Dosage information. Brimonidine ophthalmic works by decreasing the pressure in the eye. Brimonidine 0.1%, 0.15%, and 0.2% ophthalmic solutions are contraindicated for use in neonates, infants, and children younger than 2 years. It is used as eye drops or applied to the skin.. Common side effects when used in the eyes include itchiness, redness, and a dry mouth. Brimonidine is a medication used to treat open-angle glaucoma, ocular hypertension, and rosacea. How should Brimonidine be used? During postmarketing use of these ophthalmic solutions in infants, the following adverse events were noted: apnea, bradycardia, coma, hypotension, hypothermia, hypotonia, lethargy, pallor, respiratory depression, and somnolence. Apraclonidine hydrochloride (para-aminoclonidine), an α2-adrenergic agonist and clonidine derivative, is used for long-term therapy only in rare instances because of the frequent occurrence of tachyphylaxis and a hypersensitivity reaction that can cause blepharoconjunctivitis. Learn about the reported side effects, related class drugs, and how these medications will affect your daily lifestyle. Brimonidine tartrate is the most commonly used α2-adrenergic agonist. Brimonidine is a highly selective alpha-2 adrenergic receptor agonist that is 1000-fold more selective for the alpha2-adrenergic receptor than the alpha1-adrenergic receptor. Visit cvs.com for more details. Common side effects when used on the skin include redness, burning, and headaches. In rosacea it improves the redness. Brimonidine tartrate ophthalmic solution may be used concomitantly with other topical ophthalmic drug products to … One drop is usually applied to the affected eyes three times a day.